Clinical Assistant Professor Positions, DNA Diagnostics Laboratory
Yale University School of Medicine, Department of Genetics
Location: New Haven, Connecticut
Type: Full Time
Preferred Education: Doctorate
Years of Experience:
Less than 2
Internal Number: RFP-202205-924
The Department of Genetics is looking to appoint multiple faculties at the rank of Assistant Professor of Clinical Genetics to its DNA Diagnostic Laboratory - a CLIA-certified facility. The emphasis of this position is on interpretation of whole-exome sequence data and writing medical reports; the laboratory also offers rapid whole-genome sequencing and is developing novel testing based on a variety of cutting-edge methodologies.
The ideal applicant must have demonstrated clinical skill and excellence and be conversant with the standards and guidelines for medical practice by the American College of Medical Genetics (ACMG). In addition, candidates must be knowledgeable about guidelines from other professional medical associations that augment ACMG standards and that follow good practices in accordance with the College of American Pathologists (CAP) and the Clinical Laboratory Improvement Act (CLIA).
Candidates are expected to analyze high complexity sequence data (whole-exome sequence, whole-genome sequence, or mitochondrial genome sequence), and independently sign out reports and take full medico-legal responsibility for clinical information. Other responsibilities will include:
Participation in hands-on training of Laboratory Genetics and Genomics (LGG) fellows and Molecular Genetic Pathology (MGP) fellows and new clinical faculty.
Participation of other teaching and training activity for medical student, graduate student, genetic counselor and clinical residents and trainees.
Participation in maintaining laboratory standards required for CAP accreditation and CLIA certification.
Participation in maintaining carefully curated gene lists used in analysis of sequence data.
Researching and developing new laboratory procedures and computer software or databases that augment and streamline the activities of the laboratory. Contribution and participation of medical literature and scientific publication in the content of laboratory service.
While it is expected that candidates will spend most of their time working within the clinical lab, they should participate in the teaching and educational conferences and contribute to medical and/or scientific publications in the context of the lab activities.
The successful candidate should be highly motivated and have the following attributes:
Maintain the high productivity
Ability to collaborate with staff and the Lab Directors to maintain optimum working efficiency and improve financial outcomes.
Ability to aide in the curation of laboratory databases and statistical data.
Ability to communicate with health care providers regarding the reports.
Excellent written and verbal communication skills with ability to adapt between technical. and layperson communication.
Excellent organizational skills and ability to multitask and prioritize work
Attention to detail and problem-solving skills.
Ability to work independently and as part of a broader team.
The Department of Genetics has long longstanding history of excellence of developing clinical genomic tests and providing clinical care in the Yale New Haven Health System. Department of Genetics was among first to demonstrate that next generation sequencing could be used for clinical diagnosis and offer the clinical whole exome sequencing and whole genome sequencing. Clinical genetics services include inpatient consultation and outpatient care in pediatric and adult genetics that cover general genetics as well as inborn errors of metabolism. Our practice also include prenatal genetics, cancer genetics, and clinical laboratories for cytogenetic and molecular DNA diagnostics, and biochemical diagnostics. The Department sponsors a Medical Genetics Residency program and the Laboratory Genetics and Genomics (LGG) fellowship, both leading to certification by the American Board of Medical Genetics and Genomics (ABMGG).
Members of the Department of Genetics conduct basic, clinical and translational research using genetics and genomics of model organisms (yeast, fruit fly, worm, zebrafish, mouse) and humans to understand fundamental mechanisms of biology and disease. Areas of active investigation include genetic and epigenetic regulation of development and disease, molecular genetics, stem cells and other dynamic cellular systems, regulation of gene expression, computational biology and human genomics. Please see https://medicine.yale.edu/genetics for more information.
The Department of Genetics believes that outstanding science is driven by diversity. We strive to create an inclusive community of faculty, staff, and students whose voices and contributions are valued and respected, and who better represent the communities we serve. We are dedicated to providing an inclusive workplace that promotes and values diversity in age, gender identity, race, sexual orientation, physical ability and ethnicity. Diversity is our commitment and our passion; we invite you to be part of it. Please refer to the official Yale University statement on diversity and inclusion accessible here: https://medicine.yale.edu/diversity/
Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.
Candidates must hold a PhD, MD or both, and be board certified/eligible in Clinical Molecular Genetics, Laboratory Genetics and Genomics, or Molecular Genetic Pathology by the American Board of Medical Genetics and Genomics (ABMGG) or the American Board of Pathology (ABP). Strong preference is given to candidates with clinical knowledge of hereditary disease and experience with management of genome-scale sequence data. We welcome recent graduates or those who will be board-eligible by autumn 2022.
Applications should contain a cover letter, a curriculum vitae, a statement outlining clinical experience (1-2 pages), and three confidential letters of recommendation. Applicants will also be required to answer a set of questions in Interfolio pertaining to diversity and inclusion. Please email firstname.lastname@example.org for any questions about this posting.
It is expected that the successful applicant will actively contribute to our core values of diversity, innovation, and excellence in clinical genetics, and that their clinical and research interests reflects this.
About Yale University School of Medicine, Department of Genetics
The information in genomes provides the instruction set for producing each living organism on the planet. While we have a growing understanding of the basic biochemical functions of many of the individual genes in genomes, understanding the complex processes by which this encoded information is read out to orchestrate production of incredibly diverse cell types and organ functions, and how different species use strikingly similar gene sets to nonetheless produce fantastically diverse organismal morphologies with distinct survival and reproductive strategies, comprise many of the deepest questions in all of science. Moreover, we recognize that inherited or acquired variation in DNA sequence and changes in epigenetic states contribute to the causation of virtually every disease that afflicts our species. Spectacular advances in genetic and genomic analysis now provide the tools to answer these fundamental questions.
Members of the Department of Genetics conduct basic research using genetics and genomics of model organisms (yeast, fruit fly, worm, zebrafish, mouse) and humans to understand fundamental mechanisms of biology and disease. Areas of active investigation include genetic ...and epigenetic regulation of development, molecular genetics, genomics and cell biology of stem cells, the biochemistry of micro RNA production and their regulation of gene expression, and genetic and genomic analysis of diseases in model systems and humans including cancer, cardiovascular and kidney disease, neurodegeneration and regeneration, and neuropsychiatric disease. Members of the Department have also been at the forefront of technology development in the use of new methods for genetic analysis, including new methods for engineering mutations as well as new methods for production and analysis of large genomic data sets.
The Department sponsors a graduate program leading to the PhD in the areas of molecular genetics and genomics, development, and stem cell biology. Admission to the Graduate Program is through the Combined Programs in Biological and Biomedical Sciences (BBS).
In addition to these basic science efforts, the Department is also responsible for providing clinical care in Medical Genetics in the Yale New Haven Health System. Clinical genetics services include inpatient consultation and care, general, subspecialty, and prenatal genetics clinics, and clinical laboratories for cytogenetics, DNA diagnostics, and biochemical diagnostics. The Department sponsors a Medical Genetics Residency program leading to certification by the American Board of Medical Genetics. Admission to the Genetics Residency is directly through the Department.